A new study reported at this year's annual meeting of ESHRE by Dr Irene Souter of Massachusetts General Hospital and Harvard Medical School in Boston, USA, now suggests that exposure to phthalates -- as measured by levels of phthalate metabolites in urine -- is associated with reduced fertility when defined as a response to IVF treatment. " Our data support the hypothesis that exposure to specific phthalates might lead to adverse female reproductive outcomes," said Dr Souter.

The study followed the progress of 231 women (in 325 fresh treatment cycles) scheduled for IVF at the Massachusetts General Hospital between 2004 and 2012; urine samples were taken at the start of and throughout treatment and analysed for metabolites of four primary phthalates.

The association of levels of urinary metabolites was then explored with three markers of response to IVF: the number of eggs produced following ovarian stimulation, embryo development, and implantation failure.

Results first showed that urinary phthalates were detected in almost all the women, reflecting the widespread level of exposure. Results also showed:

• The odds of implantation failure increased with each rising quartile of two of the urinary phthalate metabolites. For example, for DEHP (used in vinyl plastic products) the odds of implantation failure in the highest quartile Q4) was twice that of the lowest (Q1).
• There was also an escalating decrease of 4.17% (Q2), 6.19% (Q3) and 11.4% (Q4) in the number of oocytes retrieved with each DEHP phthalate quartile when compared with Q1 (the lowest reference quartile).

The results thus showed that urinary concentrations of some commonly used phthalates were "dose-dependently" associated with a lower yield of IVF oocytes, and an increased risk of implantation failure. However, the results did not detect any association between levels of urinary phthalates and rates of fertilisation or embryo development.

Commenting, Dr Souter believes the results "support the hypothesis" that phthalates are widespread in the environment and may well have an adverse effect on female fertility, particularly when tested in the model of IVF.

"We are all primarily exposed to phthalates through inhalation and ingestion," she explained. "It is extremely difficult if not impossible to avoid exposure to phthalates, since they are in so many products." However, she added, exposure can be reduced by the following:

• Limit the use of personal care products with fragrances in them (including many of the modern baby care products and air fresheners).
• Limit use of plastic food storage containers and plastic wraps (certainly do not heat food in them).
• Read the labels and avoid children's toys made of plastics (vinyl) that contain phthalates.

Phthalates are a family of synthetic chemicals used in a wide variety of consumer products. Some phthalates (such as DEHP) are used in polyvinyl chloride (PVC, vinyl) plastics to soften them. PVC is used in the manufacture of building materials, vinyl household and industrial products, medical tubing, and blood storage bags. Some phthalates (such as DEP) are used in a wide variety of personal care products, where they are added to maintain scent and colour.