Says Bonderman: "The substance, a 'soluble gluanylate cyclase stimulator', causes the enlarged and calcified heart to become 'softer' so that it can beat more easily, after a heart attack for example. This means the pressure, which arises in the left half of the heart when the heart beats, is reduced and, consequently, the pulmonary pressure also no longer increases or is reduced. It widens the blood vessels and improves the heart's performance."

201 sufferers were involved in the current study, which has now been published in the leading journal Circulation. According to the cardiologist summarising the result, an overwhelming majority stated that after the treatment their quality of life had clearly improved and everyday activities such as going shopping or climbing stairs were easier.

Heart failure and its concomitant pulmonary hypertension lead to a reduction in performance, circulatory disorders and often to shortness of breath when lying down. Without treatment it can lead to severe heart failure. The person affected finds it difficult to walk very far or to take part in normal daily life. Heart failure is the inability of the heart to move the amount of blood required by the body without an increase in pressure in the atria of the heart and, as a result, in the lungs as well.