Neurons communicate using electrical signals. They transmit these signals to neighbouring cells via special contact points known as synapses. When new information needs processing, the nerve cells can develop new synaptic contacts with their neighbouring cells or strengthen existing synapses. To be able to forget, these processes can also be reversed. The brain is consequently in a constant state of reorganisation, yet individual neurons need to be prevented from becoming either too active or too inactive. The aim is to keep the level of activity constant, as the long-term overexcitement of neurons can result in damage to the brain.

Too little activity is not good either. "The cells can only re-establish connections with their neighbours when they are 'awake', so to speak, that is when they display a minimum level of activity," explains Mark Hübener, head of the recently published study. The international team of researchers succeeded in demonstrating for the first time that the brain is able to compensate even massive changes in neuronal activity within a period of two days, and can return to an activity level similar to that before the change.

Up to now, only cell cultures gave an indication of this astonishing ability of the brain. It was also unclear as to how neurons could control their own activity in relation to the activity of the entire network. Now, the scientists have made significant progress towards finding an answer to this question. In their study, they examined the visual cortex of mice that recently went blind. As expected, but never previously demonstrated, the activity of the neurons in this area of the brain did not fall to zero but to half of the original value. "That alone was an amazing finding, as it shows the extent to which the visual cortex also processes information from other areas of the brain," explains Tobias Bonhoeffer, who investigates processes in the visual cortex with his department at the Max Planck Institute of Neurobiology for many years. "However, things became really exciting when we continued to observe the area over the following hours and days."

The scientists were able to witness "live" through the microscope how the neurons in the visual cortex became active again. After just a few hours, they could clearly observe how the contact points between the affected neurons and their neighbouring cells increased in size. When synapses get bigger, they also become stronger and signals are transmitted faster and more effectively. As a result of this synaptic upscaling, the activity of the affected network returned to its starting value after a period of between 24 and 48 hours. "To put it simply, due to the absence of visual input, the cells had less to say -- but when they did say something, they said it with particular emphasis," explains Mark Hübener.

Due to the simultaneous strengthening of all of the synapses of the affected neurons, major reductions in the neuronal activity can be normalised again with surprising speed. The relatively stable activity level thereby achieved is an essential prerequisite for maintaining a healthy, adaptable brain.