Radiation Plus Surgery Cuts Risk of Breast Cancer Return

Oct. 20, 2011 -- Women with early breast cancer often consider breast-conserving surgery in which a doctor removes the tumor but spares the rest of the breast. But they may worry that their cancer is more likely to come back if they don't remove the entire breast.

New research shows that adding radiation therapy to breast-conserving surgery halves the chance that cancer will come back and reduces the risk of dying from breast cancer, when compared to the breast-conserving surgery alone.

The study is published in TheLancet.

Breast cancer experts tell WebMD that the new findings should provide some peace of mind for women with early breast cancer who choose breast-conserving surgery plus radiation over mastectomy -- the complete removal of the breast or breasts.

In 2011, an estimated 230,480 women will be diagnosed with breast cancer, according to the American Cancer Society. About 39,520 women will die from the disease in 2011.

The new study included close to 11,000 women who took part in 17 studies. The women were followed for about 10 years on average.

After 10 years, 35% of women who had breast-conserving surgery without radiation had a breast cancer recurrence. By comparison, 19% of women who had radiation after their breast-sparing surgery experienced a recurrence.

The study also looked at overall survival. After 15 years, 25% of women who did not have radiation had died from breast cancer, compared with 21% of these women who had both surgery and radiation. Adding radiation to treatment reduced the rate of dying from breast cancer by one-sixth, the study shows.

"For breast cancer patients treated with a lumpectomy, the addition of radiation significantly reduces the chance of the cancer coming back and most importantly improves the overall chance of ... being cured," says Thomas A. Buchholz, MD, in an email.

Buchholz, a professor and chair of the department of radiation oncology at the University of Texas M.D. Anderson Cancer Center in Houston, wrote an editorial that's published with the new study.

"The findings indicated conclusively the high benefits of radiation after lumpectomy and that these benefits persist over the entire life span of the patient. The study clearly shows that treatment at the time of diagnosis with radiation is a much better strategy than saving the treatment and using it for the patients at the time of a recurrence."