By ernando Geu-Flores, Nathaniel H. Sherden
Scientists have discovered an enzyme used in nature to make powerful chemicals from catnip to a cancer drug, vinblastine. The discovery opens up the prospect of producing these chemicals cheaply and efficiently.
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By Young-Hoo Kim, Jang-Won Park
For many years, the use of computer-assisted navigation has been touted as improving the positioning, sizing and alignment of replacement knee joints, resulting in greater durability of joints and overall improvement in patient movement. However, ne
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By Jared C. Gilliam, Juan T. Chang
Using a new technique called cryo-electron tomography, two research teams at Baylor College of Medicine have created a three-dimensional map that gives a better understanding of how the architecture of the rod sensory cilium (part of one type of pho
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By Vaida Glatt, Micah Miller, Alan Ivkovic
Bones are resilient and heal well after most fractures. But in cases of traumatic injury, in which big pieces of bone are missing, healing is much more difficult, if not impossible. These so-called "large segmental defects" are a major cli
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By D. B. Rye, D. L. Bliwise, K. Parker
Researchers at Emory University School of Medicine have discovered that dozens of adults with an elevated need for sleep have a substance in their cerebrospinal fluid that acts like a sleeping pill.
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By N. K. Logothetis, O. Eschenko
While in deep dreamless sleep, our hippocampus sends messages to our cortex and changes its plasticity, possibly transferring recently acquired knowledge to long-term memory. But how exactly is this done? Scientists from the Max Planck Institute for
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By Adam L. Hughes, Daniel E. Gottschling
For the first time, scientists at Fred Hutchinson Cancer Research Center have defined key events that take place early in the process of cellular aging. Together the discoveries, made through a series of experiments in yeast, bring unprecedented cla
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By NIH/National Heart, Lung and Blood Institute
The age-adjusted prevalence of chronic obstructive pulmonary disease (COPD) varies considerably within the United States, from less than 4 percent of the population in Washington and Minnesota to more than 9 percent in Alabama and Kentucky. These st
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By Lori S. Hart, John T. Cunningham
A pathway called the "Unfolded Protein Response," or UPR, a cell's way of responding to unfolded and misfolded proteins, helps tumor cells escape programmed cell death during the development of lymphoma.
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By Mark Mason, Jennifer J. Wanat
Chromosomes -- long, linear DNA molecules - are capped at their ends with special DNA structures called telomeres and an assortment of proteins, which together act as a protective sheath. Telomeres are maintained through the interactions between an
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By Veronica Colpani, Karen Oppermann
Moving 6,000 or more steps a day -- no matter how -- adds up to a healthier life for midlife women. That level of physical activity decreases the risk of diabetes and metabolic syndrome (a diabetes precursor and a risk for cardiovascular disease), s
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By Timothy J. Buschman, Eric L. Denovellis
One of the biggest puzzles in neuroscience is how our brains encode thoughts, such as perceptions and memories, at the cellular level. Some evidence suggests that ensembles of neurons represent each unique piece of information, but no one knows just
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By Sidong Huang, Michael Holzel
Cancer therapies often have short-lived benefits due to the emergence of genetic mutations that cause drug resistance. A key gene that determines resistance to a range of cancer drugs has been reported in a study published by Cell Press November 21s
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By Quan Wen, Michelle D. Po, Elizabeth Hulme
It's one of the basic tenets of biological research -- by studying simple "model" systems, researchers hope to gain insight into the workings of more complex organisms.
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By R. H. G. Wright, G. Castellano, J. Bonet
Two recent studies by CRG researchers delve into the role of chromatin modifying enzymes and transcription factors in tumour cells.
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By Hennady P. Shulha, Jessica L. Crisci
Short snippets of DNA found in human brain tissue provide new insight into human cognitive function and risk for developing certain neurological diseases, according to researchers from the Departments of Psychiatry and Neuroscience at Mount Sinai Sc
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By Gregory Hannum, Justin Guinney
Women live longer than men. Individuals can appear or feel years younger -- or older -- than their chronological age. Diseases can affect our aging process. When it comes to biology, our clocks clearly tick differently.
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By Christos G. Gkogkas, Arkady Khoutorsky
Researchers from McGill University and the University of Montreal have identified a crucial link between protein synthesis and autism spectrum disorders (ASD), which can bolster new therapeutic avenues.
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By Bingruo Wu, Zheng Zhang, Wendy Lui
During embryonic development, the all-important coronary arteries arise from cells previously considered incapable of producing them, according to scientists at Albert Einstein College of Medicine of Yeshiva University. The research, carried out in
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By A. H. Girgis, V. V. Iakovlev
Kidney tumours may be smarter than we thought. New research has found there are several different ways that kidney tumours can achieve the same result -- namely, grow.
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